Blocking IKKα Expression Inhibits Prostate Cancer Invasiveness
نویسندگان
چکیده
منابع مشابه
Blocking TGF-β inhibits breast cancer cell invasiveness via ERK/S100A4 signal.
OBJECTIVE Targeted down-regulation of TGF-β expression inhibits invasion and metastasis in breast cancer cells. However, the mechanism that TGF-β functions by remains largely unknown. In the present study we report the mechanism of ERK1/2 dependant S100A4 regulation by TGF-β and its possible role in TGF-β-mediated tumour invasion in vitro. MATERIALS AND METHODS Small interfering RNA targeting...
متن کاملApigenin blocks IKKα activation and suppresses prostate cancer progression
IKKα has been implicated as a key regulator of oncogenesis and driver of the metastatic process; therefore is regarded as a promising therapeutic target in anticancer drug development. In spite of the progress made in the development of IKK inhibitors, no potent IKKα inhibitor(s) have been identified. Our multistep approach of molecular modeling and direct binding has led to the identification ...
متن کاملEicosapentaenoic acid inhibits voltage-gated sodium channels and invasiveness in prostate cancer cells.
BACKGROUND AND PURPOSE The voltage-gated Na(+) channels (Na(v)) and their corresponding current (I(Na)) are involved in several cellular processes, crucial to metastasis of cancer cells. We investigated the effects of eicosapentaenoic (EPA), an omega-3 polyunsaturated fatty acid, on I(Na) and metastatic functions (cell proliferation, endocytosis and invasion) in human and rat prostate cancer ce...
متن کامل1 a , 25 - Dihydroxyvitamin D ( Calcitriol ) Inhibits the Invasiveness of Human Prostate Cancer Cells 1
la,25-Dihydroxyvitamin D (1,25 D; also known as calcitriol), the hormonal form of vitamin D, can inhibit the proliferation and promote the differentiation of human prostate adenocarcinoma cells. However, little is known about the effects of 1,25 D on the invasive ability of prostate cancer cells. We used an in vitro bioassay of cell invasion (Amgel assay) to examine the effects of 1,25 D and a ...
متن کاملERG oncoprotein inhibits ANXA2 expression and function in prostate cancer.
UNLABELLED Overexpression of ERG in the prostate epithelium, due to chromosomal translocations, contributes to prostate tumorigenesis. Here, genomic analysis of ERG siRNA-treated prostate cells harboring the endogenous TMPRSS2-ERG fusion revealed an inverse relationship between ERG and Annexin A2 (ANXA2) expression at both the RNA and protein level. ANXA2, a Ca(2+)-dependent and phospholipid-bi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2010
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-010-0351-z